
There are few dishes as universally adored as macaroni and cheese, and when you combine this classic comfort food with the savory delight of pizza, you create something truly special. Introducing the Pepperoni Pizza Macaroni and Cheese, an inventive fusion of two beloved comfort foods that brings the richness of creamy macaroni cheese and the bold flavors of pepperoni pizza into a single, irresistible casserole. This dish is a game-changer for those looking to elevate their comfort food game with something both familiar and exciting.
If you love pizza and macaroni cheese, this recipe will undoubtedly become one of your go-to comfort foods. With its gooey cheese, tender macaroni, crispy pepperoni, and pizza sauce, it offers the best of both worlds. Not only does it make for a satisfying meal, but it’s also perfect for feeding a crowd, making it an ideal choice for family dinners, potlucks, or a cozy night in.
Why You’ll Love This Pepperoni Pizza Macaroni and Cheese Recipe
This unique recipe is everything you could want from an easy casserole, yet it takes comfort foods to the next level with some delightful pizza-inspired twists. Here are a few reasons why you’ll fall in love with this dish:
- The Perfect Combination of Pizza and Mac & Cheese: Pizza and macaroni cheese are two of the most loved dishes worldwide. Combining the flavors creates an irresistible experience that combines the best of both worlds. The gooey cheese sauce, crunchy pepperoni, and rich pizza sauce create layers of flavors that meld perfectly together.
- Simple Ingredients, Big Flavor: The ingredients required for this dish are simple and readily available in most kitchens. You’ll need macaroni pasta, a selection of cheeses, pizza sauce, pepperoni, and a few spices. This means you can whip it up easily, even on busy weeknights, and still enjoy a decadent dish that feels like a treat.
- Perfect for Families and Gatherings: This easy casserole recipe serves as the ultimate comfort food that’s hearty enough to feed a crowd. Whether you’re hosting a family dinner or preparing a dish for a potluck, Pepperoni Pizza Macaroni and Cheese will satisfy everyone, including picky eaters.
- Versatile and Customizable: While the recipe includes pepperoni and pizza sauce, you can customize it to your preferences. You can add your favorite pizza toppings, such as olives, bell peppers, mushrooms, or even sausage, to make it truly your own.
- A Dish Loved by All Ages: From kids to adults, everyone can appreciate this flavorful twist on macaroni and cheese. Its combination of cheesy goodness and pizza flavor makes it a crowd-pleaser at any age.

Ingredients for Pepperoni Pizza Macaroni and Cheese
To make this hearty and comforting dish, you’ll need the following ingredients:
- Macaroni Pasta: 8 oz of elbow macaroni (or any type of pasta you prefer).
- Cheese Sauce: 2 cups of shredded mozzarella cheese (for that creamy, stretchy texture).
- Mac & Cheese Sauce: 2 cups of shredded cheddar cheese (for that sharp flavor and richness).
- Pizza Sauce: 1 cup of your favorite pizza sauce or marinara sauce.
- Pepperoni: 1 ½ cups of sliced pepperoni, or more if desired.
- Milk: 1 ½ cups of whole milk, for the creamy base of the sauce.
- Butter: 2 tablespoons of unsalted butter, which helps to create a creamy texture in the cheese sauce.
- Flour: 2 tablespoons of all-purpose flour to thicken the sauce.
- Garlic Powder: 1 teaspoon for an extra layer of flavor.
- Onion Powder: 1 teaspoon for a savory depth of flavor.
- Italian Seasoning: 1 teaspoon to give the dish a pizza-inspired twist.
- Parmesan Cheese: ¼ cup of grated Parmesan cheese to sprinkle on top for a crispy, golden finish.
- Olive Oil: For drizzling on top of the casserole to add a touch of richness and flavor.
Step-by-Step Instructions for Making Pepperoni Pizza Macaroni and Cheese
Step 1: Boil the Macaroni Pasta Start by cooking the macaroni pasta according to the package instructions. Bring a pot of salted water to a boil and cook the pasta until it is al dente, which typically takes around 7-9 minutes. Once cooked, drain the pasta and set it aside.
Step 2: Prepare the Cheese Sauce While the pasta is cooking, you can begin making the cheese sauce. In a large saucepan, melt the butter over medium heat. Once the butter is melted, sprinkle in the flour and whisk it together with the butter. Continue whisking for about 1-2 minutes to create a roux. This step helps to thicken the sauce.
Next, slowly pour in the milk while continuing to whisk to prevent any lumps from forming. Once the mixture starts to thicken, reduce the heat to low and stir in the shredded mozzarella and cheddar cheese. Continue stirring until the cheese is completely melted, and the sauce is smooth. Add garlic powder, onion powder, and Italian seasoning to give it a pizza-like flavor. Season with salt and pepper to taste.

Step 3: Mix the Macaroni and Cheese Sauce Add the cooked macaroni to the cheese sauce and stir to combine. Make sure the pasta is fully coated in the cheesy mixture.
Step 4: Add the Pizza Sauce and Pepperoni Stir in the pizza sauce, and then fold in the sliced pepperoni. You can reserve some pepperoni slices for the top if you’d like them to be crispy once baked. This adds an extra layer of flavor to the casserole, making it even more pizza-like.
Step 5: Assemble the Casserole Transfer the macaroni and cheese mixture into a greased 9×13-inch baking dish. Use a spatula to spread it out evenly.
Step 6: Add Parmesan Cheese and Bake Sprinkle the top of the casserole with grated Parmesan cheese and a little extra mozzarella if desired. Drizzle with a touch of olive oil to add richness. Place the casserole in a preheated oven at 350°F (175°C) for about 20-25 minutes, or until the top is golden and bubbly.
Step 7: Serve and Enjoy Once baked, remove the casserole from the oven and let it cool for a few minutes. This gives it time to set. Serve it up hot, and watch as everyone digs in! You can garnish with fresh basil or extra pepperoni slices for a finishing touch.

Why This Dish is a Must-Try
- Macaroni Cheese Recipes Made Better: Traditional macaroni cheese recipes are comforting on their own, but adding pizza-inspired elements like pepperoni and pizza sauce makes this recipe stand out. It’s the ultimate comfort food with a fun twist.
- Macaroni Recipes to Elevate Your Meal: If you’re tired of your standard macaroni cheese, this recipe will breathe new life into your meals. The combination of creamy cheese, tangy pizza sauce, and crispy pepperoni creates a harmonious and indulgent flavor profile.
- Easy Casserole Recipes for Busy Weeknights: This is an easy casserole recipe that’s quick to prepare and can be made in advance. It’s the perfect weeknight dinner when you don’t want to spend hours in the kitchen but still want a meal that’s both hearty and satisfying.
- Pepperoni Pizza Lovers’ Dream: If you’re a pepperoni pizza fan, you’ll be in heaven. The pepperoni crisps up as it bakes, giving it that authentic pizza flavor and texture. It’s a great way to get your pizza fix without actually ordering takeout.
- Comfort Foods for All Ages: Whether you’re a kid or an adult, there’s no denying that this dish will satisfy your cravings for comfort foods. It’s cheesy, savory, and absolutely delicious.
Conclusion
Pepperoni Pizza Macaroni and Cheese is the perfect dish for anyone who loves both pizza and macaroni cheese. With its gooey cheese, tender pasta, tangy pizza sauce, and crispy pepperoni, it’s a comfort food lover’s dream come true. This easy casserole recipe is perfect for family dinners, gatherings, or simply when you want to indulge in some classic comfort food with a twist.
The best part? It’s incredibly easy to make, using simple ingredients that you likely already have in your kitchen. Whether you’re cooking for a crowd or just your family, this dish is sure to be a hit. So the next time you’re craving something indulgent and comforting, reach for this Pepperoni Pizza Macaroni and Cheese recipe and enjoy a warm, cheesy, and delicious meal that everyone will love!